Keratin hydrolysates are active components used in food supplements to alleviate aging signs on skin, hair, and nails. This randomized, double-blind,placebo-controlled study evaluates a novel keratin hydrolysate obtained from poultry feathers.

The primary objective of this study was to evaluate the maintenance of skin homeostasis and the anti-aging/ moisturizing efficacy of the tested products. Specifically, skin wrinkles, skin roughness, skin firmness and elasticity, skin gloss, deep skin moisturization, skin thickness, and skin fiber network were evaluated. Secondary objectives of this study were to evaluate the effect of the tested products in improving hair gloss, nail gloss, and nail hardness/aspect.

Ninety-nine (n = 99) healthy women were enrolled by dermatologists according to the following inclusion criteria: subjects aged between 35 and 65 years old, phototypes I–IV clinically showing physiological aging signs, visible face roughness (crow’s feet wrinkles), mild to moderate skin sagging, damaged/brittle hair, and brittle nails.

In this study, each participant took four capsules per day (two at breakfast and two at dinner) of the placebo or the test product with a glass of water for 90 days, providing a dosage of 500 or 1000 mg of FKH per day.

Safety and efficacy assessments included three visits: a baseline visit (D0), an intermediate visit after 45 days (D45), and a final visit after 90 days (D90) of product intake.

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