Throughout life, the skin is subjected to internal and external factors influencing both its biological response and its appearance. All these factors are known as the exposome and play a pivotal role in premature aging. Among them, solar radiation and air pollution are exposomal factors that dramatically accelerate skin aging by inducing oxidative stress and inflammaging.

A randomized split-face study was carried out on 22 adult female outdoor workers between 40 and 65 years old, using an artichoke leaf extract.

The study endpoints included the measurement of the following parameters: skin radiance (8° gloss parameter), skin profilometry (wrinkle depth and skin roughness), total skin antioxidant capacity (FRAP assay), and TNF-α cytokine dosage. These endpoints were chosen because of their correlation with the ageing process and to demonstrate the product’s efficacy in supporting well-aging of the skin.

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