Cognitive decline, a common consequence of aging, detrimentally affects independence, physical activity, and social interactions. This decline encompasses various cognitive functions, including processing speed, memory, language, and executive functioning.

Grape juice is mainly characterized by the presence of anthocyanins (i.e., malvidin and cyanidin) and proanthocyanidins which include monomers, oligomers, and more complex polymers; the main proanthocyanidins are catechin, epicatechin, procyanidin B1, and procyanidin B2.

Complife study, with a double-blind, placebo-controlled clinical trial on 96 healthy older adults, the efficacy of once-daily 250 mg of a standardized grape (Vitis vinifera L.) juice extract in improving short- and long-term cognitive functions.

This trial aimed to confirm the long-term activity already described in the literature, and to investigate, for the first time, the immediate and early-term activity of a standardized grape extract, using the most recognized and scientifically approved tests.

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